A Furostanol Glycoside from Garlic, Bulbs of Allium sativum L.

Abstract

A new furostanol glycoside (1) was isolated from garlic, bulbs of Allium sativum L. (Liliaceae), and the structure was established to be 26-O-β-glucopyranosyl 22-hydroxy-25(R)-5α-furostane-3β, 6β, 26-triol 3-O-β-glucopyranosyl(1→2)-[β-glucopyranosyl(1→3)]-β-glucopyranosyl-(1→4)-β-galactopyranoside, i.e., proto-eruboside-B. Eruboside-B (3) obtained by enzymatic hydrolysis of 1 inhibited the growth of Candida albicans in vitro (25 μg/ml MIC).