Effects of Glutathione, as the Dextran Conjugate, on Acetaminophen-Induced Hepatotoxicity

Abstract

Glutathione was covalently attached to dextra, (T-40) by the CNBr activation method. In mive given a lethal dose of acetaminophen, the 30-d survival rate increased progressicively with coadministration of the conjugate, whereas little improvement was found when free glutathione was given. The dextran conjugate of glutathione maintaied the serum transaminase activities at lower levels after acetaminophen administration, giving effective protection against acetaminophen hepatotoxicity.