Amino Acids and Peptides. XI. : Simple Preparation of Nα-Protected Histidine

Koichi KAWASAKI; Masanori MIYANO; Tomohiro MURAKAMI; Mihoko KAKIMI

doi:10.1248/cpb.37.3112

Amino Acids and Peptides. XI. : Simple Preparation of N^α-Protected Histidine

Koichi KAWASAKI, Masanori MIYANO, Tomohiro MURAKAMI, Mihoko KAKIMI

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Keywords: histidine, N^α-protected histidine, tert-butoxycarbonylhistidine, p-methoxybenzyloxycarbonylhistidine, benzyl-oxycarbonylhistidine, ion-exchange chromatography

JOURNAL FREE ACCESS

1989 Volume 37 Issue 11 Pages 3112-3113

DOI https://doi.org/10.1248/cpb.37.3112

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Abstract

Since most N^α-protected histidines are water-soluble, their preparation and purification are troublesome. We have developed a simple and easy purification procedure for the preparation of N^α-protected histidines, such as Boc-His-OH, Z-His-Oh and Z(OMe)-His-OH, using ion-exchange column chromatography.

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