Regioselective Introduction of a Methoxy Group at the Benzylic Position of Isochromane Derivatives by Cerium(IV) Oxidation in Methanol

Kimiaki ISOBE; Naoko TAKEDA; Kunihiko MOHRI; Yoshisuke TSUDA

doi:10.1248/cpb.37.3390

Kimiaki ISOBE, Naoko TAKEDA, Kunihiko MOHRI, Yoshisuke TSUDA

Author information

Keywords: ceric ammonium nitrate (CAN), methanol, regioselective methoxylation, isochromane, methoxyisochroman-3-one, benzylic oxidation, methoxylation

JOURNAL FREE ACCESS

1989 Volume 37 Issue 12 Pages 3390-3392

DOI https://doi.org/10.1248/cpb.37.3390

Details

Abstract

The oxidation of methoxy-isochromans and -isochromanones with ceric ammonium nitrate in methanol introduced a new methoxy group regioselectively at a benzylic position para to the methoxy function on the aromatic nucleus.

Corresponding author

Register with J-STAGE for free!