GANODERIC ACID AND ITS DERIVATIVES AS CHOLESTEROL SYNTHESIS INHIBITORS

Yasuo KOMODA; Masato SHIMIZU; Yoshiko SONODA; Yoshihiro SATO

doi:10.1248/cpb.37.531

Yasuo KOMODA, Masato SHIMIZU, Yoshiko SONODA, Yoshihiro SATO

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Keywords: cholesterol synthesis, Ganoderma lucidum, oxygenated lanosterol derivative, [24, 25-³H]-24, 25-dihydrolanosterol, ganoderic acid derivative, ganoderic acid derivative, inhibitory activity, chemical conversion

JOURNAL FREE ACCESS

1989 Volume 37 Issue 2 Pages 531-533

DOI https://doi.org/10.1248/cpb.37.531

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Abstract

Oxygenated lanosterol derivatives, which were isolated from Ganoderma lucidum (Polyporaceae) or their derivatives obtained by chemical conversion, were tested for their effect on cholesterol biosynthesis from 24, 25-dihydrolanosterol by rat hepatic subscellular 10, 000 x g supernatant fraction. The sterol (VI, 40 μM) with 7-oxo and 15α-hydroxy groups potently inhibited the synthesis of cholesterol from [24, 25-³H]-24, 25-dihydrolanosterol (18 μM).

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