A New Pharmacological Testing Method : Different Effects of Levamisole and the Serum of Mice Orally Treated with Levamisole on Mitogenic Activity of Lipopolysaccharide

Abstract

The direct addition of levamisole to murine splenic lymphocytes had no effect on the mitogenic activity of lipopolysaccharide. However, the addition of serum of mice orally treated with levamisole increased the mitogenic activity, and this increased activity using serum was similar to the result obtained in an in vivo experiment. These results suggest that the new in vitro experimental method using serum may be able to reproduce the in vivo effect of drugs.