1989 Volume 37 Issue 4 Pages 988-992
From the aerial parts of Ajuga ciliata var. villosior, nine new neo-clerodane diterpenes have been isolated. The structures of two acetyl derivatives of (12S)-6α, 12, 19-trihydroxy-1β-[(2S)-2-methylbutanoyloxy]-4, 18-epoxyneo-clerod-13(14)-en-15, 16-olide, three acetyl derivatives of (12S)-1β, 6α, 19-trihydroxy-12-[(2S)-2-metthylbutanoyloxy]-4, 18-epoxyneo-clerod-13(14)-en-15, 16-olide, three acetyl derivatives of (12S)-6α, 19-dihydroxy-12-[(2S)-2-mehylbutanoyl-oxy]-4, 18-epoxyneo-clerod-13(14)-en-15, 16-olide and methyl 6α-hydroxy-4α-methoxycarbonyl-18-norneo-clerod-13(14)-en-15, 16-olide were elucidated by spectroscopic methods and chemical correlation. In addition, a known neo-clerodane, ajugarin-IV, was isolated.
