Isolation of Inhibitors of Adenylate Cyclase from Dan-shen, the Root of Salvia miltiorrhiza

Hiroshi KOHDA; Osamu TAKEDA; Seiji TANAKA; Kazuo YAMASAKI; Atsushi YAMASHITA; Tomonori KUROKAWA; Sadahiko ISHIBASHI

doi:10.1248/cpb.37.1287

Hiroshi KOHDA, Osamu TAKEDA, Seiji TANAKA, Kazuo YAMASAKI, Atsushi YAMASHITA, Tomonori KUROKAWA, Sadahiko ISHIBASHI

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Keywords: dan-shen, Salvia miltiorrhiza, adenylate cyclase, rosemarinic acid, lithospermic acid

JOURNAL FREE ACCESS

1989 Volume 37 Issue 5 Pages 1287-1290

DOI https://doi.org/10.1248/cpb.37.1287

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Abstract

The effect of dan-shen extract, the root of Salvia miltiorrhiza, on adenylate cyclase was investigated in both rat brain and rat erythrocytes. The EtOAc fraction of the MeOH extract was proved to have significant inhibitory activity. Potent inhibitory principles in the EtOAc fraction were isolated and identified as 4 polyphenolic acids, rosemarinic acid, lithospermic acid, and their methyl ester derivatives.

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