FACILE PREPARATION OF UNSTABLE METABOLIC INTERMEDIATES : EPOXIDE(S) OF PYRAZOLO[1, 5-a]PYRIDINE DERIVATIVES BY THE CYTOCHROME P-450 CHEMICAL MODEL

Yoshio NAGATSU; Tsunehiko HIGUCHI; Masaaki HIROBE

doi:10.1248/cpb.37.1410

Yoshio NAGATSU, Tsunehiko HIGUCHI, Masaaki HIROBE

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Keywords: pyrazolo[1, 5-a]pyridine derivative, epoxidation, metabolic intermediate, drug metabolism, P-450 chemical model, metalloporphyrin

JOURNAL FREE ACCESS

1989 Volume 37 Issue 5 Pages 1410-1412

DOI https://doi.org/10.1248/cpb.37.1410

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Abstract

Biomimetic oxidation of bioactive pyrazolo[1, 5-a]pyridine derivatives carried out with the chemical model for cytochrome P-450, afforded 6, 7-epoxides in relatively high yields, these appear to be chemically unstable precursors of the main metabolites, i__-.e__-., 6, 7-dihydro-6, 7-diols.

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