A NEW METHOD FOR MEASURING IONOPHORETIC ACTIVITY USING A GLASS-CELL APPARATUS EQUIPPED WITH ARTIFICIAL MEMBRANES

Isao KITAGAWA; Kazuyoshi OHASHI; Wakuko KOYAMA; Hiroyuki KAWANISHI; Toshihiro YAMAMOTO; Takao NISHINO; Hirotaka SHIBUYA

doi:10.1248/cpb.37.1416

Isao KITAGAWA, Kazuyoshi OHASHI, Wakuko KOYAMA, Hiroyuki KAWANISHI, Toshihiro YAMAMOTO, Takao NISHINO, Hirotaka SHIBUYA

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Keywords: ion-transport activity, liquid membrane apparatus, ionophore, crown ether, theonellapeptolide Id, merremoside a, merremoside h₁, oligopeptide-lactone ionophore, resin-glycoside lactone ionophore

JOURNAL FREE ACCESS

1989 Volume 37 Issue 5 Pages 1416-1418

DOI https://doi.org/10.1248/cpb.37.1416

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Abstract

A simple apparatus for measuring the ion-transport activity of a substance has been developed. The apparatus designated W-07 comprises three parts : two glass-cells of aqueous phase sandwiching one teflon cell of organic phase with two artificial membranes in between. Using the apparatus W-07, we have demonstrated the ion-transport activities (for Na⁺, K⁺, and Ca⁺⁺ ions) of an oligopeptide-lactone, and resin-glycosides containing a macrocyclic lactone structure.

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