SYNTHESIS OF (-)-ARISTEROMYCIN FROM D-GLUCOSE

Masayuki YOSHIKAWA; Yoshihiko OKAICHI; Bae Cheon CHA; Isao KITAGAWA

doi:10.1248/cpb.37.2555

Masayuki YOSHIKAWA, Yoshihiko OKAICHI, Bae Cheon CHA, Isao KITAGAWA

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Keywords: (-)-aristeromycin, carbocyclic nucleoside antibiotic, pseudo-nucleoside, nitro-cyclopentene, Michael-type addition reaction, pseudo-aminosugar, D-glucose, D-allofuranose

JOURNAL FREE ACCESS

1989 Volume 37 Issue 9 Pages 2555-2557

DOI https://doi.org/10.1248/cpb.37.2555

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Abstract

(-)-Aristeromycin, a carbocyclic nucleoside with various biological activities, was synthesized from D-glucose using a Michael-type addition reaction of N⁶-benzoyladenine with a nitro-cyclopentene derivative as its key step.

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