A SIMPLE DIASTEREOSELECTIVE SYNTHESIS OF CYCLOHEXYLNORSTATINE AND ALLOCYCLOHEXYLNORSTATINE

Hiromu HARADA; Atsushi TSUBAKI; Tetsuhide KAMIJO; Kinji IIZUKA; Yoshiaki KISO

doi:10.1248/cpb.37.2570

Hiromu HARADA, Atsushi TSUBAKI, Tetsuhide KAMIJO, Kinji IIZUKA, Yoshiaki KISO

Author information

Keywords: cyclohexylnorstatine, allocyclohexylnorstatine, α-hydroxy-β-amino acid, transition-state analogue, renin inhibitor

JOURNAL FREE ACCESS

1989 Volume 37 Issue 9 Pages 2570-2572

DOI https://doi.org/10.1248/cpb.37.2570

Details

Abstract

Cyclohexylnorstatine [(2R, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (1) and allocyclohexylnorstatine [(2S, 3S)-3-amino-4-cyclohexyl-2-hydroxybutyric acid] (2), designed as key amino acids in renin inhibitors, were synthesized diastereoselectively and simply from Boc-L-phenylalaninol.

Corresponding author

Register with J-STAGE for free!