Inhibitors of Skin-Tumor Promotion. VIII. : Inhibitory Effects of Euglobals and Their Related Compounds on Epstein-Barr Virus Activation. (1)

Midori TAKASAKI; Takao KONOSHIMA; Kazuyoshi FUJITANI; Shigeo YOSHIDA; Hiroyuki NISHIMURA; Harukuni TOKUDA; Hoyoku NISHINO; Akio IWASHIMA; Mutsuo KOZUKA

doi:10.1248/cpb.38.2737

Midori TAKASAKI, Takao KONOSHIMA, Kazuyoshi FUJITANI, Shigeo YOSHIDA, Hiroyuki NISHIMURA, Harukuni TOKUDA, Hoyoku NISHINO, Akio IWASHIMA, Mutsuo KOZUKA

Author information

Midori TAKASAKI
Takao KONOSHIMA
Kazuyoshi FUJITANI
Shigeo YOSHIDA
Hiroyuki NISHIMURA
Harukuni TOKUDA
Hoyoku NISHINO
Akio IWASHIMA
Mutsuo KOZUKA
Author's Organization：
Kyoto Pharmaceutical University
Kyoto Pharmaceutical University
Kyoto Pharmaceutical University
Institute of Physical and Chemical Research
Department of Bioscience and Technology, Scool of Engineering, Hokkaido Tokai University
Department of Biochemistry, Kyoto Prefectural University of Medicine
Department of Biochemistry, Kyoto Prefectural University of Medicine
Department of Biochemistry, Kyoto Prefectural University of Medicine
Kyoto Pharmaceutial University

Keywords: Epstein-Barr virus, euglobal, acylphloroglucinol, monoterpenoid, sesquiterpenoid, Eucalyptus globulus, TPA, anti-tumor-promoter, structural requirement

JOURNAL FREE ACCESS

1990 Volume 38 Issue 10 Pages 2737-2739

DOI https://doi.org/10.1248/cpb.38.2737

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Abstract

Twelve euglobals from Eucalyptus globulus and their twenty-six related compounds were examined for their inhibitory effects on Epstein-Barr virus activation by a short-term in vitro assay. The results showed that most of the euglobals having monoterpene structures, and euglobal-III (8) had strong inhibitory activity. Grandinol (18), homograndinols (19 and 20), and compounds 26, 27, 28, and 32 showed stronger inhibitory effects. Based on the results, the structural requirements for the activity of these compounds were discussed.

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