Synthesis of 8-Amino-5, 6-quinolinediones from 6-Quinolinols and 5, 6-Dimethoxyquinolines

Abstract

Twenty-five 8-amino-5, 6-quinolinediones were prepared by copper(II)-catalyzed oxidation of 6-quinolinol in methanol with secondary amines, or by oxidative demethylation of the corresponding 5, 6-dimethoxyquinolines in aqueous acetonitrile with cerium(IV) ammonium nitrate.