Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Possible Applicatin of Polyamine Graft Copolymer to Targeting Drug Delivery
村松 延弘吉田 靖近藤 保
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1990 年 38 巻 11 号 p. 3175-3176

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Polystyrene microspheres were coated with polyamine graft copolymer and mixed with rat lymphocyte suspension.In the mixture of T and B cells, the microspheres formed large aggregates, while they were fairly well dispersed in the T cell suspension. This result was understood to be the result of preferential adsorption of B cells to the microspheres, indicating it would be possible to deliver drugs to B cells alone with these copolymer-coated microspheres.
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© The Pharmaceutical Society of Japan
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