Organic Phosphorus Compounds. IV : Asymmetric 4-(Benzothiazol-2-yl)benxylphosphonates as Potent Calcium Antagonistic Vasodilators

Kohichiro YOSHINO; Katsumi GOTO; Toshihiko KOHNO; Tominori MORITA; Goro TSUKAMOTO

doi:10.1248/cpb.38.676

Kohichiro YOSHINO, Katsumi GOTO, Toshihiko KOHNO, Tominori MORITA, Goro TSUKAMOTO

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Keywords: fostedil, coronary vasodilator, calcium antagonist, phosphonic acid, phosphonate, benzothiazole

JOURNAL FREE ACCESS

1990 Volume 38 Issue 3 Pages 676-680

DOI https://doi.org/10.1248/cpb.38.676

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Abstract

Various asymmetric or cyclic ester derivatives of the phosphonic acid moiety in the calcium antagonist fostedil (KB-944) were synthesized. The coronary vasodilator activity of these compounds was assessed by Langendorff's method. Among them, the ethyl isopropyl ester 12 showed the most potent activity, which was comparable to that of fostedil.

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