Abstract
Anti-allergic activities of lyophilized pig bile ([PB]) were examined in mice with picryl chloride-induced contact dermatitis (PC-CD), an experimental model of delayer-type hepersensitivity (DTH; type-IV allergy). PC-CD was markedly inhibited by an oral administration of [PB] within 4h after but not during 8 to 16h after challenge with picryl chloride.Anti-inflammatory activities of [PB] were also examined in acetic acid-induced mouse increased vascular permeability, hypetonic-hyperthermic lysis of rat erythrocytes and carrageenin-induced rat hind paw edema. [PB] had no effect on these models. The present study suggests that[PB] inhibits PC-CD through its immuno-modulation in the inductive phase of DTH rather than by an anti-inflammatory action.
