Studies on Cardiotonic Agents. I. : Synthesis of Some Quinazoline Derivatives

Yuji NOMOTO; Hiroyuki OBASE; Haruki TAKAI; Tadashi HIRATA; Masayuki TERANISHI; Joji NAKAMURA; Kazuhiro KUBO

doi:10.1248/cpb.38.1591

Yuji NOMOTO, Hiroyuki OBASE, Haruki TAKAI, Tadashi HIRATA, Masayuki TERANISHI, Joji NAKAMURA, Kazuhiro KUBO

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Keywords: positive inotropic activity, cardiotonic agent, structure-activity relationship, quinazoline, piperidine

JOURNAL FREE ACCESS

1990 Volume 38 Issue 6 Pages 1591-1595

DOI https://doi.org/10.1248/cpb.38.1591

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Abstract

A series of quinazoline derivatives with various 4-heterocyclylpiperidino groups at the 4-position was synthesized and tested for cardiotonic activity in anesthetized dogs. Among them, several 6, 7-dimethoxyquinazoline derivatives showed potent cardiotonic activity.

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