Triterpenoids from the Fruits of Phellodendron chinense SCHNEID. : : The Stereostructure of Niloticin

Ronghui SU; Mujo KIM; Hitoshi KAWAGUCHI; Takehiko YAMAMOTO; Katsumi GOTO; Tooru TAGA; Yoshihisa MIWA; Mutsuo KOZUKA; Shozo TAKAHASHI

doi:10.1248/cpb.38.1616

Ronghui SU, Mujo KIM, Hitoshi KAWAGUCHI, Takehiko YAMAMOTO, Katsumi GOTO, Tooru TAGA, Yoshihisa MIWA, Mutsuo KOZUKA, Shozo TAKAHASHI

Author information

Ronghui SU
Mujo KIM
Hitoshi KAWAGUCHI
Takehiko YAMAMOTO
Katsumi GOTO
Tooru TAGA
Yoshihisa MIWA
Mutsuo KOZUKA
Shozo TAKAHASHI
Author's Organization：
Central Research Laboratories, Taiyo Kagaku Co., Ltd.,
Central Research Laboratories, Taiyo Kagaku Co., Ltd.,
Central Research Laboratories, Taiyo Kagaku Co., Ltd.,
Department of Biotechnology, Fukuyama University
The Garden of Medicinal Plants, Kyoto Pharmaceutical University
Faculty of Pharmaceutical Sciences, Kyoto University
Faculty of Pharmaceutical Sciences, Kyoto University
Kyoto Pharmaceutical University
Pesticide Research Institute, Facutly

Keywords: stereostructure, X-ray analysis, niloticin, phellochin, melianone, Phellodendron chinense, triterpenoid, limonoid

JOURNAL FREE ACCESS

1990 Volume 38 Issue 6 Pages 1616-1619

DOI https://doi.org/10.1248/cpb.38.1616

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Abstract

Three tirucallane-type triterpenoids, niloticin, phellochin and melianone, were isolated from the fruits of Phellodendron chinense SCHNEID. (Rutaceae). The stereostructure of niloticin was determined based on spectroscopic and X-ray crystal structure analyses. Furthermore, a derivative of niloticin and two derivatives of melianone were also found. A possible biogenetic pathway in P. chinense is proposed : niloticin → melianone → limonoids, on the basis of isolation of the compounds in different oxidation states.

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