A Large-Scale Synthesis of [MeTry1, MeArg7, D-Leu8]Dynorphin A-(1-8)-NHEt (E-2078) by Application of the Trifluoroacetic Acid-Pentamethylbenzene Deprotecting Procedure in the Final Stage

Hiroshi YOSHINO; Masahiko TSUJII; Masato KODAMA; Keisuke KOMEDA; Nobuo NIIKAWA; Takaaki TANASE; Naoki ASAKAWA; Koichi NOSE; Kiyomi YAMATSU

doi:10.1248/cpb.38.1735

A Large-Scale Synthesis of [MeTry¹, MeArg⁷, D-Leu⁸]Dynorphin A-(1-8)-NHEt (E-2078) by Application of the Trifluoroacetic Acid-Pentamethylbenzene Deprotecting Procedure in the Final Stage

Hiroshi YOSHINO, Masahiko TSUJII, Masato KODAMA, Keisuke KOMEDA, Nobuo NIIKAWA, Takaaki TANASE, Naoki ASAKAWA, Koichi NOSE, Kiyomi YAMATSU

Author information

Keywords: dynorphin A, octapeptide, large-scale synthesis, trifluoroacetic acid-pentamethylbenzene, E-2078

JOURNAL FREE ACCESS

1990 Volume 38 Issue 6 Pages 1735-1737

DOI https://doi.org/10.1248/cpb.38.1735

Details

Abstract

A large-scale synthesis of [MeTyr¹, MeArg⁷, D-Leu⁸]dynorphin A-(1-8)-NHEt (E-2078), which is a systemically active dynorphin A-(1-8) analogue, was accomplished by the classical solution method applying the trifluoroacetic acid-pentamethylbenzene deprotecting procedure in the final stage.

Corresponding author

Register with J-STAGE for free!