Ga-Labeling of Immunoglobulin G with High Specific Radioactivity

Takako FURUKAWA; Yasuhisa FUJIBAYASHI; Masao FUKUNAGA; Akira YOKOYAMA

doi:10.1248/cpb.38.2285

古川高子, 藤林靖久, 福永仁夫, 横山陽

著者情報

キーワード: ^<67>Ga purification, deferoxamine, ^<67>Ga-deferoxamine-IgG, IgG labeling, high specific radioactivity

ジャーナルフリー

1990 年 38 巻 8 号 p. 2285-2286

DOI https://doi.org/10.1248/cpb.38.2285

詳細

抄録

To obtain radiogallium labeled immunoglobulin G with a high specific radioactivity for in vitro use, a ⁶⁷Ga source was purified by extraction from ⁶⁷Ga-gallium citrate with butyl acetate, and a ⁶⁷Ga-labeling solution was produced. This solution was then used to label a deferoxamine-immunoglobulin G conjugate. Both a very high specific radioactivity(872±56 MBq/mg) and a high labeling efficiency (94.0%) were achieved.

責任著者(Corresponding author)

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