An Improved Method for the Synthesis of Arylacetonitriles from 3-Aryl-2-hydroxyiminopropionic Acids Using 1, 1'-Oxalyldiimidazole

Tokujiro KITAGAWA; Megumi KAWAGUCHI; Misuzu IKIUCHI

doi:10.1248/cpb.39.187

Tokujiro KITAGAWA, Megumi KAWAGUCHI, Misuzu IKIUCHI

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Keywords: 1, 1'-oxalydiimidazole, arylacetonitrile, 3-aryl-2-hydroxyiminopropionic acid, dehydration, decarboxylation

JOURNAL FREE ACCESS

1991 Volume 39 Issue 1 Pages 187-189

DOI https://doi.org/10.1248/cpb.39.187

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Abstract

1, 1'-Oxalyldiimidazole (ODI, 3) is a useful reagent for the degradation of 3-aryl-2-hydroxyiminopropionic acids (2) into the corresponding arylacetonitriles (1) under essentially neutral conditions.

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