著者所属：Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Central Research Laboratories, Banyu Pharmaceutical Co., Ltd.,
Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3"-hydroxy and 3', 3"-dihydroxy-Δ4', 5' derivatives of simvastatin.
