Synthesis of 2-Substituted 1, 3, 4-Thiadiazol-5-ylacetic, Propionic, and Gltaric Acids

Kouhei TOYOOKA; Takayuki KASAI; Shiro HORI; Yasushi KAWASHIMA; Masayuki SHIBUYA; Seiju KUBOTA

doi:10.1248/cpb.39.2837

Kouhei TOYOOKA, Takayuki KASAI, Shiro HORI, Yasushi KAWASHIMA, Masayuki SHIBUYA, Seiju KUBOTA

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Keywords: 2, 3-dihydro-1, 3, 4-thiadiazole, 2-substituted 1, 3, 4-thiadiazol-5-ylacetate, 2-benzoyl-1, 3, 4-thiadiazol-5-ylacetic acid, ethyl bromoacetate, alkylation, hydrolysis, 1, 3, 4-thiadiazol-5-ylpropionic acid, 1, 3, 4-thiadiazol-5-ylglutaric acid

JOURNAL FREE ACCESS

1991 Volume 39 Issue 11 Pages 2837-2841

DOI https://doi.org/10.1248/cpb.39.2837

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Abstract

1, 3, 4-Thiadiazol-5-ylacetic, propionic, and glutaric acids (3-5) were synthesized via ethyl 2-substituted 1, 3, 4-thiadiazol-5-ylacetates (11 and 17) as key intermediates.

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