Asymmetric syntheses of 1-Alkyltetrahydro-β-carbolines and a 9-Thio Analogue

Nazumul QAIS; Noriyoshi NAKAO; Kuniko HASHIGAKI; Yasuo TAKEUCHI; Masatoshi YAMATO

doi:10.1248/cpb.39.3338

Nazumul QAIS, Noriyoshi NAKAO, Kuniko HASHIGAKI, Yasuo TAKEUCHI, Masatoshi YAMATO

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Keywords: tetrahydro-β-carboline, (S)-tetrahydroharman, (S)-aryltetrahydro-β-carboline, tetrahydrobenzo[4, 5]thieno[2, 3-c]pyridine, phenylglycinol, asymmetric synthesis

JOURNAL FREE ACCESS

1991 Volume 39 Issue 12 Pages 3338-3340

DOI https://doi.org/10.1248/cpb.39.3338

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Abstract

Tetrahydro-β-carbolines, (S)-tetrahydroharman (8a) and (S)-1-phenyltetrahydro-β-carboline (8b), were asymmetrically synthesized starting from (R)-phenylglycinol and 1-benzyl-3-(2-bromoethyl)indole (1). Asymmetric synthesis of the 9-thio analogue (15) of 8a was also achieved.

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