Analgesic Principles from Aralia cordata THUNB.

Emi OKUYAMA; Satoshi NISHIMURA; Mikio YAMAZAKI

doi:10.1248/cpb.39.405

Emi OKUYAMA, Satoshi NISHIMURA, Mikio YAMAZAKI

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Keywords: Aralia cordata, Kyohkatsu, Dokukatsu, Qiang-huo, Du-huo, (ent)-kaur-16-en-19-oic acid, (ent)-pimara-8(14), 15-dien-19-oic acid, pharmacologically active principle, analgesics

JOURNAL FREE ACCESS

1991 Volume 39 Issue 2 Pages 405-407

DOI https://doi.org/10.1248/cpb.39.405

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Abstract

The analgesic principles from Aralia cordata THUNB. were identified with (ent)-kaur-16-en-19-oic acid (KA) and (ent)-pimara-8(14), 15-dien-19-oic acid (PA), respectively. Both compounds were significantly effective regarding analgesics, hypothermia, duration of pentobarbital-induced anesthesia, and depression of locomotor activity enhanced by methamphetamine at doses of 300 mg/kg (KA) and 500 mg/kg (PA) by oral administration.

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