THE CHEMICAL REPAIR REACTION OF THYMINE AND THYMIDINE DIOL DERIVATIVES, MODELS OF OXIDATIVELY DAMAGED NUCLEIC ACIDS, BY TRIVALENT PHOSPHORUS COMPOUNDS

Reiko YANADA; Kiyoshi BESSHO; Takashi HARAYAMA; Fumio YONEDA

doi:10.1248/cpb.39.1333

Reiko YANADA, Kiyoshi BESSHO, Takashi HARAYAMA, Fumio YONEDA

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Keywords: 1, 3-dimethylthymine diol, thymidine diol derivative, phosphite, phosphine, reduction, repair reaction, damaged nucleic acid model, mechanism

JOURNAL FREE ACCESS

1991 Volume 39 Issue 5 Pages 1333-1334

DOI https://doi.org/10.1248/cpb.39.1333

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Abstract

When treated with trivalent phosphorus compounds, thymine and thymidine diol derivatives, models of oxidatively damaged nucleic acids, were reductively repaired to regenerate the original thymine and thymidine derivatives. A possible mechanism is proposed.

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