Studies on Hypotensive Agents. Synthesis of 1-Substituted 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5, 7-dimethyl-2, 4(1H, 3H)-quinazolinediones

Abstract

3-(2-Chlorophenyl)-6-ethoxycarbonyl-5, 7-dimethyl-2, 4(1H, 3H)-quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activites on relaxing effects of the blood vessels. The compounds with 2-(1-pyrroidinyl) ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.