Isolation of Neoanisatin Derivatives from the Pericarps of Illicium majus with Other Constituents

Abstract

Further studies on the constituents of Illicium majus have resulted in the isolation of five new neoanisatin derivatives and two known phytoquinoides together with two known neolignans. Two of the neoanisatin derivatives are 1-hydroxyl, which are the first examples isolated anisatin derivatives so far. Another one, 2-oxoneoanisatin, exhibited picrotoxin-like convulsions in mice, the same as anisatin. THe otehr two 3, 4-dehydroxy-2-oxoneoanisatin isomers could not be separated from each other, even with high performance liquid chromatography.