A Stereoselective Synthesis of (±)-Pestalotin

Toshio HONDA; Akihiko OKUYAMA; Tomohisa HAYAKAWA; Hirotsune KONDOH; Masayoshi TSUBUKI

doi:10.1248/cpb.39.1866

Toshio HONDA, Akihiko OKUYAMA, Tomohisa HAYAKAWA, Hirotsune KONDOH, Masayoshi TSUBUKI

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Keywords: (±)-pestalotin, tetronate, syn-glycol, stereoselective reduction, ethyl diazoacetate

JOURNAL FREE ACCESS

1991 Volume 39 Issue 7 Pages 1866-1868

DOI https://doi.org/10.1248/cpb.39.1866

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Abstract

(±)-Pestalotin (1) was synthesized by employing a stereoselective reduction of a 5-alkyltetronate derivative (3) and a two-carbon elongation reaction of the aldehyde (13) with ethyl diazoacetate in the presence of stannous chloride as key steps.

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