Structures of Americanol A and Isoamericanol A Having a Neurotrophic Property from the Seeds of Phytolacca americana

Yoshiyasu FUKUYAMA; Takashi HASEGAWA; Miki TODA; Mitsuaki KODAMA; Hiroshi OKAZAKI

doi:10.1248/cpb.40.252

Yoshiyasu FUKUYAMA, Takashi HASEGAWA, Miki TODA, Mitsuaki KODAMA, Hiroshi OKAZAKI

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Keywords: americanol A, isoamericanol A, americanin A, isoamericanin A, neo-lignan, 1, 4-benzodioxane, Phytolacca americana, Phytolaccaceae, choline acetyltransferase, neurotrophic activity

JOURNAL FREE ACCESS

1992 Volume 40 Issue 1 Pages 252-254

DOI https://doi.org/10.1248/cpb.40.252

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Abstract

The structures of new neo-lignans, isoamericanol A (1) and americanol A (2) isolated from the seeds of Phytolacca americana have been elucidated on the basis of spectroscopic data and then confirmed by chemical correlation with the previouslty known isoamericanin A (3) and americanin A (4). Isoamericanol A, americanol A, and americanin A have been found to enhance choline acetyltransferase activity at 10^-5 M in a cultured neuronal cell system derived from fetal rat hemisphere.

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