Isolation and Identification of a Cytotoxic Principle from Chrysosplenium grayanum MAXIM. (Saxifragaceae) and Its Antitumor Activities

Munehisa ARISAWA; Hua BAI; Shoji SHIMIZU; Saburo KOSHIMURA; Motohiro TANAKA; Takuma SASAKI; Naokata MORITA

doi:10.1248/cpb.40.3274

Munehisa ARISAWA, Hua BAI, Shoji SHIMIZU, Saburo KOSHIMURA, Motohiro TANAKA, Takuma SASAKI, Naokata MORITA

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Keywords: β-peltoboykinolic acid, hydroxyoleanen-27-oic acid, Chrysosplenium grayanum, cytotoxicity, antitumor effect, B16-BL6 mouse melanoma, Meth·A mouse fibrosarcoma, combination therapy

JOURNAL FREE ACCESS

1992 Volume 40 Issue 12 Pages 3274-3276

DOI https://doi.org/10.1248/cpb.40.3274

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Abstract

A cytotoxic principle was newly isolated from Chrysosplenium grayanum MAXIM. (Saxifragaceae) and identified as β-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth·A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.

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