1992 Volume 40 Issue 12 Pages 3311-3313
The solubility change of thiamine disulfide (TDS) in 1, 2-dichloroethane by the addition of fatty acid (FA), fatty alcohol or fatty acid methyl ester was determined by phase solubility analysis at 25°C. The solubility of TDS increased linearly with added concentrations of stearic acid, palmitic acid or myristic acid, but the diagram did not exhibit a plateau due to the appearance of a solid complex. The dependency of the FA slope values on the number of carbon atoms in FA was very little. The solubility of TDS also incerased linearly with added concentrations of stearyl alcohol, while the value for the slope was smaller than FA. On the other hand, the solubility of TDS decreased by the addition of stearic acid methyl ester. The results agreed well with those for the solubilization of cycotiamine, a thiamine derivative, by FA and FA analogs in 1, 2-dichloroethane.
