THUNBERGINOLS C, D, AND E, NEW ANTIALLERGIC AND ANTIMICROBIAL DIHYDROISOCOUMARINS, AND THUNBERGINOL G 3'-O-GLUCOSIDE AND (-)-HYDRANGENOL 4'-O-GLUCOSIDE, NEW DIHYDROISOCOUMARIN GLYCOSIDES, FROM HYDRANGEAE DULCIS FOLIUM

Masayuki TOSHIKAWA; Emiko UCHIDA; Nobuyasu CHATANI; Hiromi KOBAYASHI; Yoshikazu NAITOH; Yasuhiro OKUNO; Hisashi MATSUDA; Johji YAMAHARA; Nobutoshi MURAKAMI

doi:10.1248/cpb.40.3352

Masayuki TOSHIKAWA, Emiko UCHIDA, Nobuyasu CHATANI, Hiromi KOBAYASHI, Yoshikazu NAITOH, Yasuhiro OKUNO, Hisashi MATSUDA, Johji YAMAHARA, Nobutoshi MURAKAMI

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Keywords: Hydrangeae Dulcis Folium, Hydrangea mactophylla var. thunbergii, thunberginol C, thunberginol D, thunberginol E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-O-glucoside, antiallergic activity, antimicrobial activity, dihydroisocoumarin

JOURNAL FREE ACCESS

1992 Volume 40 Issue 12 Pages 3352-3354

DOI https://doi.org/10.1248/cpb.40.3352

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Abstract

New antiallergic and antimicrobial dihydroisocoumarins, thunberginols C, D, and E, were isolated from Hydrangeae Dulcis Folium, the fermented and dried leves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO, together with new dihydroisocoumarin glycosides, thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside. Their chemical structures have been determined on the basis of chemical and physicochemical evidence. Thunberginols C, D, E, G, and (-)-hydrangenol 4'-O-glucoside showed antiallergic activity in the in vitro bioassay using the Schults-Dale reaction in sensitized guinea pig bronchial muscle, and they also exhibited antimicrobial activity against oral bacteria.

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