Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
The Alkylation of 6-Chloropurine with Alcohols by Mitsunobu Reaction
Akemi TOYOTA(nee MIZUTANI), Nobuya KATAGIRI, Chikara KANEKO
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Keywords: Mitsunobu reaction, 6-chloropurine, 9-substituted purine, 7-substituted purine, alkylation, adenine
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1992 Volume 40 Issue 4 Pages 1039-1041

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Abstract
A general procedure has been developed for the preparetion of 9-alkylated adenines by the Mitsunobu reaction between 6-chloropurine and several alcohols, followed by the replacement of the chlorine with ammonia. A lesser amount of the 7-alkylpurines was also obtained, irrespective of the alcohol used.
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© The Pharmaceutical Society of Japan
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