Electrochemical Methoxylation of Arylacetates

Mitsuko KATO; Shohei SUZUKI; Miyako SHIMAMURA; Koohei NOZAWA; Ken-ichi KAWAI; Shoichi NAKAJIMA

doi:10.1248/cpb.40.1037

Mitsuko KATO, Shohei SUZUKI, Miyako SHIMAMURA, Koohei NOZAWA, Ken-ichi KAWAI, Shoichi NAKAJIMA

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Keywords: active methylene, electrochemical hydroxylation, electrochemical methoxylation, electron carrier, methoxide anion, 1-naphthaleneacetate, phenylacetate

JOURNAL FREE ACCESS

1992 Volume 40 Issue 4 Pages 1037-1038

DOI https://doi.org/10.1248/cpb.40.1037

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Abstract

Electrochemical methoxylation at the active methylene group of phenylacetates and 1-naphthaleneacetate was conducted successfully at room temperature, in methanol containing potassium iodide as an electron carrier and solium methoxide as a bade and a methoxylating agent. Along with the mono-methoxylated products, dimethoxy, hydroxy, and oxo derivatives as well as the dimers (succinates) were produced as by-products.

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