THE ORIGIN OF THE ENANTIOSELECTION IN THE RUTHENIUM(II)-CATALYZED ASYMMETRIC HYDROGENATION OF α, β-UNSATURATED CARBOXYLIC ACID

Kiyoshi YOSHIKAWA; Masanao MURATA; Naoko YAMAMOTO; Kiyoshi INOGUCHI; Kazuo ACHIWA

doi:10.1248/cpb.40.1072

Kiyoshi YOSHIKAWA, Masanao MURATA, Naoko YAMAMOTO, Kiyoshi INOGUCHI, Kazuo ACHIWA

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Keywords: atropisomeric biphenylbisphosphine, ruthenium(II) complex, asymmetric hydrogenation, pressure effect, tiglic acid, angelic acid

JOURNAL FREE ACCESS

1992 Volume 40 Issue 4 Pages 1072-1074

DOI https://doi.org/10.1248/cpb.40.1072

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Abstract

Using our chiral atropisomeric bisphosphines ruthenium(II) complexes, asymmetric hydrogenations of tiglic acid and its isomer were carried out. A possible enantioselective mechanism was considered on the basis of their different results on hydrogenation pressure effects.

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