ENANTIOMERIC DIFFERENCE IN PERCUTANEOUS PENETRATION OF PROPRANOLOL THROUGH RAT EXCISED SKIN

Keisuke MIYAZAKI; Fusao KAIHO; Aiko INAGAKI; Masahiko DOHI; Norio HAZEMOTO; Makoto HAGA; Hiroshi HARA; Yuriko KATO

doi:10.1248/cpb.40.1075

Keisuke MIYAZAKI, Fusao KAIHO, Aiko INAGAKI, Masahiko DOHI, Norio HAZEMOTO, Makoto HAGA, Hiroshi HARA, Yuriko KATO

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Keywords: percutaneous penetration, enantiomeric difference, R-(+)-propranolol, S-(-)-propranolol, normal skin, damaged skin, rat, flux, in vitro

JOURNAL FREE ACCESS

1992 Volume 40 Issue 4 Pages 1075-1076

DOI https://doi.org/10.1248/cpb.40.1075

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Abstract

The percutaneous penetration of R-(+)- and S-(-)-propranolol (PL) through rat excised skin was investigated in vitro. The flux of S-(-)-PL after application to normal skin was high compared with that of R-(+)-PL. On the other hand, in damaged rat skin, the flux of R-(+)-PL was almost equivalent to that of S-(-)-PL. It is suggested that there is an enantiomeric difference between S-(-)- and R(+)-PL in terms of penetration through rat stratum corneum.

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