Syntheses of 7-Alkyl-1, 3, 6-trimethylpyrrolo[2, 3-d]pyrimidines and 4-Alkylamino-2, 5-dimethyl-2, 3-dihydrofuro[3, 2-e]pyrimidines

Ichiro ISHIKAWA; Victor E. KHACHATRIAN; Raphael G. MELIK-OHANJANIAN; Norio KAWAHARA; Yoshihisa MIZUNO; Haruo OGURA

doi:10.1248/cpb.40.846

Ichiro ISHIKAWA, Victor E. KHACHATRIAN, Raphael G. MELIK-OHANJANIAN, Norio KAWAHARA, Yoshihisa MIZUNO, Haruo OGURA

Author information

Keywords: pyrrolo[2, 3-d]pyrimidine, 5-allylbarbituric acid, 5-allyl-6-chlorouracil, palladium-catalyzed cyclization, PdCl₂-(CH₃CN)₂, furo[3, 2-e]pyrimidine

JOURNAL FREE ACCESS

1992 Volume 40 Issue 4 Pages 846-850

DOI https://doi.org/10.1248/cpb.40.846

Details

Abstract

7-Alkyl-1, 3, 6-trimethylpyrrolo[2, 3-d]pyrimidine-2, 4(1H, 3H)-diones were readily synthesized by treatment of 6-alkylamino-5-allyl-1, 3-dimethyluracils, which were derived from 5-allyl-6-chloro-1, 3-dimethyluracil and alkylamines, with bis(acetonitrile) palladium (II) chloride. In addition, 4-alkylamino-2, 5-dimethyl-2, 3-dihydrofuro[3, 2-e]pyrimidin-6-ones were easily synthesized by treatment of 5-allyl-6-chloro-1-methyluracil with alkylamines.

Corresponding author

Register with J-STAGE for free!