Syntheses of a Glycerophospholipid, C16-Platelet Activating Factor and a Palmitoyl Analogue of M-5, an Anti-inflammatory Glyceroglycolipid

Hirotaka SHIBUYA; Keiko KAWASHIMA; Norihiko NARITA; Isao KITAGAWA

doi:10.1248/cpb.40.1166

Hirotaka SHIBUYA, Keiko KAWASHIMA, Norihiko NARITA, Isao KITAGAWA

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Keywords: complex lipid, glycerolipid, glycerophospholipid, chiral C4-epoxide, glycerol derivative optically active, platelet activating factor C16, anti-inflammatory glyceroglycolipid, metal radical epoxide-ring opening

JOURNAL FREE ACCESS

1992 Volume 40 Issue 5 Pages 1166-1169

DOI https://doi.org/10.1248/cpb.40.1166

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Abstract

From a chiral C4-epoxide (-)-3, which is one of the synthons in our synthetic strategy for complex lipids, a glycerophospholipid C16-platelet activating factor (C16-PAF, 1) and a palmitoyl analogue (2) of an anti-inflammatory glyceroglycolipid M-5, which was previously isolated from the Okinawan marine sponge Phyllospongia foliascens, have been synthesized.

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