A Chlorine-Containing neo-Clerodane Diterpene from Teucrium pernyi

Ning XIE; Zhi-da MIN; Shou-xun ZHAO; Yang LU; Qi-tai ZHENG; Chunshu WANG; Mizuo MIZUNO; Munekazu IINUMA; Toshiyuki TANAKA

doi:10.1248/cpb.40.2193

Ning XIE, Zhi-da MIN, Shou-xun ZHAO, Yang LU, Qi-tai ZHENG, Chunshu WANG, Mizuo MIZUNO, Munekazu IINUMA, Toshiyuki TANAKA

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Keywords: Teucrium pernyl, Labiatae, chlorine-containing diterpene, neo-clerodane, teupernin D

JOURNAL FREE ACCESS

1992 Volume 40 Issue 8 Pages 2193-2195

DOI https://doi.org/10.1248/cpb.40.2193

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Abstract

A novel chlorine-containing neo-clerodane diterpene, teupernin D, and two known compounds, teucvidin and teuflin, were isolated from the whole parts of Teucrium pernyi. The structure of teupernin D was characterized as (12S)-15, 16-epoxy-8β-hydroxy-17-chloro-19-nor-10α-neo-cleroda-4, 13, 14-triene-18, 6β : 20, 12-diolide on the basis of spectral evidence. The absolute configuration was established by the circular dichroism (CD) spectrum and confirmed by X-ray crystallographic analysis.

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