Studies on Thermophile Products. IV. Structural Elucidation of Cytotoxic Substance, BS-1, Derived from Bacillus stearothermophilus

Yasuhiro KOHAMA; Kentaro IIDA; Taro SEMBA; Tsutomu MIMURA; Akira INADA; Keishi TANAKA; Tsutomu NAKANISHI

doi:10.1248/cpb.40.2210

Yasuhiro KOHAMA, Kentaro IIDA, Taro SEMBA, Tsutomu MIMURA, Akira INADA, Keishi TANAKA, Tsutomu NAKANISHI

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Keywords: B. stearothermophilus, cytotoxicity, structure, bis(2-hydroxyethyl) trisulfide, leukemia, mastocytoma, lymphoma

JOURNAL FREE ACCESS

1992 Volume 40 Issue 8 Pages 2210-2211

DOI https://doi.org/10.1248/cpb.40.2210

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Abstract

A new cytotoxic substance designated as BS-1 was isolated from the autolysate and culture filtrate of Bacillus stearothermophilus UK563. On the basis of spectral data, the structure of BS-1 was determined as bis(2-hydroxyethyl) trisulfide and confirmed by direct comparison with the synthetic compound. BS-1 exhibited potent cytotoxicity against leukemia P388-D1, leukemia P388, mastocytoma P815, lymphoma EL4 and lymphoma MOLT4.

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