Palbinone, a Novel Terpenoid from Peaonia albiflora; Potent Inhibitory Activity on 3α-Hydroxysteroid Dehydrogenase

Abstract

Palbinone, a novel terpenoid isolated from the roots of Paeonia albiflora, showed a strong inhibitory activity on the reduced from of nicotinamide adenine dinucleotide phosphate (NADPH)-linked 3α-hydroxysteroid dehydrogenase(3α-HSD) of rat liver cytosol. The structures of palbinone and a known compound, paeonilactone-B isolated from the active fraction of this plant were determined by the use of 2D NMR techniques (¹H-¹H COSY, ¹H-¹³C COSY, ¹H-¹³C-long-range COSY, and HMBC).