A Convenient Preparation of Salicylaldehydes from 2-Methylbenzofurans by Ozonolysis

Hisashi ISHII; Shuji OHTA; Hiromi NISHIOKA; Naomi HAYASHIDA; Takashi HARAYAMA

doi:10.1248/cpb.41.1166

Hisashi ISHII, Shuji OHTA, Hiromi NISHIOKA, Naomi HAYASHIDA, Takashi HARAYAMA

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Keywords: salicylaldehyde, 2-methylbenzofuran, ozonolysis, benzofuran ring cleavage, ruthenium tetroxide, osmium tetroxide

JOURNAL FREE ACCESS

1993 Volume 41 Issue 6 Pages 1166-1168

DOI https://doi.org/10.1248/cpb.41.1166

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Abstract

A convenient and effective transformation of 2-methylbenzofuran (B) to salicylaldehyde (C) was achieved by ozonolysis of B in CH₂Cl₂ at -78°C followed by alkaline hydrolysis.

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