The 1H- and 13C-Nuclear Magnetic Resonance Spectra of Manzamine C and Related Compounds

Hiroko SEKI; Masako NAKAGAWA; Akihiro HASHIMOTO; Tohru HINO

doi:10.1248/cpb.41.1173

The ¹H- and ¹³C-Nuclear Magnetic Resonance Spectra of Manzamine C and Related Compounds

Hiroko SEKI, Masako NAKAGAWA, Akihiro HASHIMOTO, Tohru HINO

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Keywords: ^1H-NMR, ^<13>C-NMR, 2D-NMR, ^1H-detected heteronuclear multiple bond connectivity (HMBC), manzamine C, β-carboline

JOURNAL FREE ACCESS

1993 Volume 41 Issue 6 Pages 1173-1176

DOI https://doi.org/10.1248/cpb.41.1173

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Abstract

The ¹H- and ¹³C-NMR spectra of manzamine C (1) and its analogs (2-8) have been analyzed by applying HC-COSY (or HMQC) and COLOC (or HMBC) methods. The slow ring-inversion of the piperidine part in 6 was observed at room temperature. The free energy of activation for interconversion of rotamers in the amide analog (8) was evaluated.

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