Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
CONFORMATION OF TROPOLONE RING IN ANTILEUKEMIC TROPOLOISOQUINOLINE ALKALOIDS
Hiroshi MORITA, Kouji MATSUMOTO, Koichi TAKEYA, Hideji ITOKAWA
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Keywords: conformation, puckering, tropolone, tropoloisoquinoline alkaloid, NMR, simulated annealing
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1993 Volume 41 Issue 8 Pages 1478-1480

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Abstract
Conformational analysis of antileukemic tropoloisoquinoline alkaloids isolated from Cissampelos pareira was conducted by thermodynamic proton nuclear magnetic resonance (1H NMR) studies. The line-broadening of one of methoxy methyl signals can be explained by the tropolone ring-puckering process. Analysis by dynamical simulated annealing and modified neglect of differential overlap (MNDO) calculations also supported puckering of tropolone ring system.
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© The Pharmaceutical Society of Japan
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