GENERAL METHOD FOR DETERMINATION OF CONFIGURATION OF STEROID-17-YL METHYL GLYCOLATES AT C-20

Toshio SUZUKI; Hitoshi TADA; Yasuyuki MATSUDA; Xiao-hong YANG; Katsuo UNNO

doi:10.1248/cpb.41.1481

Toshio SUZUKI, Hitoshi TADA, Yasuyuki MATSUDA, Xiao-hong YANG, Katsuo UNNO

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Keywords: anti-inflammatory steroid, C-20 configuration, conformational analysis, methoxycarbonylation, dioxolanone

JOURNAL FREE ACCESS

1993 Volume 41 Issue 8 Pages 1481-1483

DOI https://doi.org/10.1248/cpb.41.1481

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Abstract

Kinetic examination for methoxycarbonylations of the isomeric steroid-17-yl methyl glycolates at C-20 and plots of the amount of each isomer produced by a reaction of their corresponding steroids with cupric acetate in absolute methanol provide a general and facile method for determination of the configuration of the steroid-17-yl methyl glycolates at C-20.

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