Synthesis and Antitmor Activities of Prodrugs of Benzoylphenylureas

Hiroshi OKADA; Tohru KOYANAGI; Nobutoshi YAMADA

doi:10.1248/cpb.42.57

Hiroshi OKADA, Tohru KOYANAGI, Nobutoshi YAMADA

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Keywords: benzoylphenylurea, antitumor agent, prodrug, N-[4-(2-pyrimidinyloxy)phenyl]carbamoyl-2-nitrobenzimidate, N-acyl-N"-(2-nitrobenzoyl)-N-[4-(2-pyrimidinyloxy)phenyl]urea

JOURNAL FREE ACCESS

1994 Volume 42 Issue 1 Pages 57-61

DOI https://doi.org/10.1248/cpb.42.57

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Abstract

Various benzoylphenylurea derivatives were synthesized as candidate prodrugs and their antitumor activities were examined in vivo against P388 leukemia. All of the prodrugs were soluble in most organic solvents and showed good antitumor activities against P388 leukemia cells in mice when dosed intraperitoneally or orally.

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