2, 2'-Disubstituted Biphenyls : Synthesis and Suppressive Effect against Carbon Tetrachloride-Induced Liver Injury

Kazuhiko KONDO; Masami TAKAHASHI; Hiroshi OHMIZU; Mamoru MATSUMOTO; Ikuhiko TAGUCHI; Tameo IWASAKI

doi:10.1248/cpb.42.62

Kazuhiko KONDO, Masami TAKAHASHI, Hiroshi OHMIZU, Mamoru MATSUMOTO, Ikuhiko TAGUCHI, Tameo IWASAKI

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Keywords: 2, 2'-disubstituted biphenyl, Ullmann coupling reaction, liver-protective activity, carbon tetrachloride-induced liver injury

JOURNAL FREE ACCESS

1994 Volume 42 Issue 1 Pages 62-66

DOI https://doi.org/10.1248/cpb.42.62

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Abstract

2, 2'-Disubstituted biphenyl compounds (1-15) were synthesized by using the Ullmann coupling reaction as a key step. The suppressive effect of these compounds against CCl₄-induced liver injuries in mice was evaluated. An unsymmetrical biphenyl (14f) exhibited the most potent activity. The structure-activity relationship is discussed.

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