Synthesis of Artificial Glycoconjugates of Arginine-Vasopressin and Their Antidiuretic Activities

Hiroshi SUSAKI; Kokichi SUZUKI; Masahiro IKEDA; Harutami YAMADA; Hiroshi K. WATANABE

doi:10.1248/cpb.42.2090

洲崎浩, 鈴木幸吉, 池田政浩, 山田治民, 渡辺宏

著者情報

キーワード: arginine-vasopressin, glycoconjugate, antidiuretic activity, solid-phase synthesis, glucose, galactose

ジャーナルフリー

1994 年 42 巻 10 号 p. 2090-2096

DOI https://doi.org/10.1248/cpb.42.2090

詳細

抄録

Argiine-vasopressin (AVP) derivatives modified at the glutamine side chain amide with carbohydrate via an alkylene spacer (1a-d) were synthesized from new glycosylated glutamine derivatives (3a-d) by solid-phase synthesis. Glycoconjugates of AVP modified at the C-terminal amide (2a-d) were also synthesized from vasopressionic acid. All of them exhibited antidiuretic activity.

責任著者(Corresponding author)

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